Carl Johnson, CJ, the game's main character, has been living in Liberty City for the past five years or so, supposedly trying to escape Los Santos where he grew up. The real reason however, is to avoid dealing with the death of his ten year old brother Brian, and he's managing to get by until yesterday when his older brother calls him up to tell him that his mother has been killed. He immediately hops back on a plane to go home to Los Santos to be with his family. As soon as CJ gets to Los Santos he is picked-up by a couple of crooked cops who dump him in a rival gang's territory. Exactly at that point in time, the gamer, you, comes in.
Los Santos, San Andreas is a city tearing itself apart with gang trouble, drugs and corruption. It is a city where filmstars and millionaires do their best to avoid the dealers and gangbangers.
The timeline of the game is the early 90s and CJ will be forced on a journey that will take him across the entire state of San Andreas, to save his family and to take control of the streets.